Endocrine Abstracts

We aimed to identify causal mutation(s) in 2 patients (P1 and P2) with thyroid dyshormonogenesis (TD) from a consanguineous Tunisian family. Patient P1 developed TD at age 10; while P2 developed it at a late age (30 years) with no goiter. Scintigraphy showed homogeneous uptake of 131I in P1 patient. Genetic analysis was performed using candidate gene approach. Thus, sequencing of the 17 exons of the TPO gene revealed only presence of rs4927611 polymorphism ...

Introduction: Lipemic specimens could be a source of significant analytical errors. The aim of this study was to examine the effect of lipid removal using ultra-centrifugation of lipemic samples, on some routine biochemistry parameters.Observation: A 53-year-old man hospitalized in endocrinology department for treatment of severe hypertriglyceridemia (21.3 mmol/l). All the patient’s routine biochemical parameters were held on AU 680®...

Introduction: Mitochondrial diabetes (MD) is characterized by a broad spectrum of phenotypic and genotypic involvement. Through a cohort study of 40 patients with DM, we tried to correlate this diversity of phenotypic expression with the biomolecular substratum of the mitochondrial genome in the Tunisian population.Results: Epidemiologically and anthropometrically, our series fits the literature data with age at 31.6 years (5–52), female predominanc...

Introduction: Diabetes, like any chronic disease, generates in addition to the somatic consequences, serious psychological repercussions, depression and diabetes emerging respectively in the 4th and 9th rank of the most important causes of disturbances in number of years of life corrected for the disability factor. (DALYS).Patients and methods: Descriptive retrospective study of 38 post-Covid diabetics collected from the endocrinology – diabetology ...

Background: Fibroscan is a noninvasive medical dispositive for the evaluation of hepatic fibrosis based on the technique of pulse elastography. However, the interpretation of its value depends on several parameters.Objective: The purpose of our work is to study the impact of diabetes on the value of liver fibroscan and to identify possible factors influencing this value in diabetics.Materials and methodes: Our work is a cross-secti...

Introduction:: The association of breast cancer and neuroendocrine tumours, in particular pheochromocytoma, is rarely described in the literature. We report a case in a particular context.Observation: This is a 53-year-old patient treated with 6 courses of chemotherapy for T2N3cM0 infiltrating breast carcinoma. She was admitted to our endocrinology department for exploration of a left adrenal incidentaloma, objectified in the extension assessment, measur...

IntroductionPrimary ovarian failure currently represents an increasingly frequent cause for consultation in endocrinology, from 4 to 18 % of the causes of primary amenorrhea and 10 to 28 % of the causes of secondary amenorrhea.ObjectivesIn this context, we report a retrospective study of 50 patients followed between 2000 and 2020 for early menopause, in order to assess the etiologies and risk factors favourin...

IntroductionRecent studies in patients with Addison’s disease (AD) have shown that this condition, even if treated, is fraught with significant morbidity. In this context, we report a retrospective study which concerned 32 patients with AD in order to determine the deleterious effects of long-term glucocorticoid substitution, mainly on the occurrence of type 2 diabetes.ResultsIn the 32 patients followed ...

IntroductionSelf-esteem is widely viewed as a person’s overall evaluation about self-worth or personal value and is considered an essential indicator for positive mental health and psychological well-being. This study sought to explore the level of self-esteem and identify the factors associated with low self-esteem in this population.MethodsIt was a cross-sectional study conducted in Sfax, Southern Tuni...

Introduction: Multiple endocrine neoplasia (MEN) is a group of inherited syndromes of autosomal dominant transmission characterized by the development of endocrine tumors.Materials and methods: It is a retrospective study collecting data of 9 patients with MEN, during a 30-year period.Results: The mean age at diagnosis was 34.6 years with a clear female predominance. The majority of our patients were from Gabes (4 cases). Seven pat...